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GDC-0941 Dimethanesulfonate

A potent, selective, inhibitor of pan-class I PI3 kinase
Catalog #: 9618
SKU-Size Size Price Qty
9618-10 10 mg
$135.00
9618-50 50 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name 4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine;methanesulfonic acid; Pictilisib
Appearance White to off-white solid
CAS # 957054-33-0
Molecular Formula C₂₅H₃₅N₇O₉S₄
Molecular Weight 705.85
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6.CS(=O)(=O)O.CS(=O)(=O)O
InChi InChI=1S/C23H27N7O3S2.2CH4O3S/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19;2*1-5(2,3)4/h2-4,13-14H,5-12,15H2,1H3,(H,24,27);2*1H3,(H,2,3,4)
InChi Key RFRIKACSFOTIMU-UHFFFAOYSA-N
PubChem CID 56972143
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GDC-0941 is a potent, selective, inhibitor of pan-class I PI3 kinase (PI3K), with IC₅₀ values of 3, 33, 3, 75, 1230 and 580 nM for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively. Displays antineoplastic activity.


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Yichun Zhu. Interferon gamma induces inflammatory responses through the interaction of CEACAM1 and PI3K in airway epithelial cells. J Transl Med May-19. 31072323.
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