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GDC-0068

A potent pan-Akt inhibitor
Catalog #: 2667
SKU-Size Size Price Qty
2667-1 1 mg
$95.00
2667-5 5 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name (S)-2-(4-chlorophenyl)-1-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-(isopropylamino)propan-1-one; Ipatasertib
Appearance Off-white solid
CAS # 1001264-89-6
Molecular Formula C₂₄H₃₂ClN₅O₂
Molecular Weight 458
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
SMILES CC1CC(C2=C1C(=NC=N2)N3CCN(CC3)C(=O)C(CNC(C)C)C4=CC=C(C=C4)Cl)O
InChi nChI=1S/C24H32ClN5O2/c1-15(2)26-13-19(17-4-6-18(25)7-5-17)24(32)30-10-8-29(9-11-30)23-21-16(3)12-20(31)22(21)27-14-28-23/h4-7,14-16,19-20,26,31H,8-13H2,1-3H3/t16-,19-,20-/m1/s1
InChi Key GRZXWCHAXNAUHY-NSISKUIASA-N
PubChem CID 24788740
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GDC-0068 is a potent, ATP-competitive, pan-Akt inhibitor with IC₅₀s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively. Displays selectivity over more than other 200 screened kinases. Potential anticancer agent.


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