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GDC-0032

A potent, and selective inhibitor of Class I PI3-K α, δ, and γ isoforms, with 30-fold less inhibition of the PI3K β isoform relative to the PI3K α isoform.
Catalog #: 9573
SKU-Size Size Price Qty
9573-5 5 mg
$125.00
9573-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 2-methyl-2-[4-[2-(5-methyl-2-propan-2-yl-1,2,4-triazol-3-yl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]pyrazol-1-yl]propanamide; Taselisib
Appearance White to off-white solid
CAS # 1282512-48-4
Molecular Formula C₂₄H₂₈N₈O₂
Molecular Weight 460.53
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES CC1=NN(C(=N1)C2=CN3CCOC4=C(C3=N2)C=CC(=C4)C5=CN(N=C5)C(C)(C)C(=O)N)C(C)C
InChi InChI=1S/C24H28N8O2/c1-14(2)32-22(27-15(3)29-32)19-13-30-8-9-34-20-10-16(6-7-18(20)21(30)28-19)17-11-26-31(12-17)24(4,5)23(25)33/h6-7,10-14H,8-9H2,1-5H3,(H2,25,33)
InChi Key BEUQXVWXFDOSAQ-UHFFFAOYSA-N
PubChem CID 51001932
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

GDC-0032 is a potent, and selective inhibitor of Class I PI3-K α, δ, and γ isoforms, with 30-fold less inhibition of the PI3K β isoform relative to the PI3K α isoform. This next generation PI3-K inhibitor displays increased anti-tumor activity against PIK3CA mutant (MT) cell lines.


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