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GCK (Glucokinase) Antibody

Catalog #: 3154
$325.00

Product Details

Cat # +Size 3154-100
Size 100 µg
Antibody Target GCK (Glucokinase)
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide selected from the C-terminal region of human GCK
Accession # P35557
Gene ID 2645
Appearance Colorless liquid
Concentration 0.25 mg/ml
Formulation 100 µg (0.25 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification Affinity purified
Species Reactivity Human, mouse
Application ELISA, Western blot, Immunohistochemistry
Application & Usage The antibody can be used for ELISA (0.25 µg/ml), Western Blotting (0.5 – 2.5 µg/ml) and Immunohistochemistry (2.5 – 5.0 µg/ml).
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of the gene for GCK results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in the gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), also called maturity onset diabetes of the young, type 2 (MODY2); mutations have also been associated with persistent hyperinsulinemic hypoglycemia of infancy (PHHI).


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Can you provide more details for us on the immunogen sequence?
Immunogen sequence is a synthetic polypeptide with amino acid sequence range from aa 403 – aa 433.