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GBR-12909

A potent and selective inhibitor of dopamine uptake
Catalog #: B3043
SKU-Size Size Price Qty
B3043-5 5 mg
$85.00
B3043-25 25 mg
$340.00
More Sizes Get Quote

Product Details

Alternate Name Vanorexine; Vanoxerin; 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine; Vanoxerina; Vanoxerinum
Appearance Solid powder
CAS # 67469-69-6
Molecular Formula C₂₈H₃₂F₂N₂O
Molecular Weight 450.56
Purity ≥98%
Solubility Soluble in DMSO
SMILES C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
InChi InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2
InChi Key NAUWTFJOPJWYOT-UHFFFAOYSA-N
PubChem CID 3455
MDL Number MFCD00600385
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

GBR-12909 is a potent and selective inhibitor of dopamine uptake (Ki = 1 nM). It inhibits dopamine uptake in tissue slices obtained from rat neostriatum at nanomolar concentrations. GBR-12909 (10 mg/kg IP) produces a dose-dependent decrease in the binding of cocaine to the dopamine transporter in rats. It antagonizes the ability of cocaine to elevate extracellular dopamine. It is also a potent blocker of cardiac hERG, sodium and calcium channels and shows cardiac antiarrhythmic properties. It is a potent ligand for sigma receptor. Regulators of sigma receptors are suggested to show activity against COVID-19, based on viral assay screens.


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