Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]


A potent and selective inhibitor of dopamine uptake
Catalog #: B3043
SKU-Size Size Price Qty
B3043-5 5 mg
B3043-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name Vanorexine; Vanoxerin; 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine; Vanoxerina; Vanoxerinum
Appearance Solid powder
CAS # 67469-69-6
Molecular Formula C₂₈H₃₂F₂N₂O
Molecular Weight 450.56
Purity ≥98%
Solubility Soluble in DMSO
InChi InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2
PubChem CID 3455
MDL Number MFCD00600385
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


GBR-12909 is a potent and selective inhibitor of dopamine uptake (Ki = 1 nM). It inhibits dopamine uptake in tissue slices obtained from rat neostriatum at nanomolar concentrations. GBR-12909 (10 mg/kg IP) produces a dose-dependent decrease in the binding of cocaine to the dopamine transporter in rats. It antagonizes the ability of cocaine to elevate extracellular dopamine. It is also a potent blocker of cardiac hERG, sodium and calcium channels and shows cardiac antiarrhythmic properties. It is a potent ligand for sigma receptor. Regulators of sigma receptors are suggested to show activity against COVID-19, based on viral assay screens.

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.