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A potent histone acetyltransferases (HATs) p300 inhibitor
Catalog #: 2088
SKU-Size Size Price Qty
2088-5 5 mg
2088-25 25 mg
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Product Details

Alternate Name Camboginol
Appearance Yellow solid
CAS # 78824-30-3
Molecular Formula C₃₈H₅₀O₆
Molecular Weight 602.8
Purity ≥95% by TLC
Solubility DMSO (25 mg/ml) or EtOH (25 mg/ml)
InChi InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21H2,1-6,8-10H3
PubChem CID 3531
MDL Number MFCD03700761
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50 = 7 µM) and PCAF (IC50 = 5 µM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions. Garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.

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