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GANT61

A Hedgehog (Hh) signaling pathway antagonist
Catalog #: 1892
$165.00

Product Details

Cat # +Size 1892-5
Size 5 mg
Alternate Name 2,​2'-​[[dihydro-​2-​(4-​pyridinyl)-​1,​3(2H,​4H)-​pyrimidinediyl]bis(methylene)]bis(N,​N-​dimethyl-​benzenamine); NSC 136476
Appearance White to off-white solid
CAS # 500579-04-4
Molecular Formula C₂₇H₃₅N₅
Molecular Weight 429.6
Purity ≥98% by HPLC
Solubility DMSO (>2 mg/ml)
SMILES CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C
InChi InChI=1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3
InChi Key KVQOGDQTWWCZFX-UHFFFAOYSA-N
PubChem CID 421610
MDL Number MFCD14635408
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A Hedgehog (Hh) signaling pathway antagonist. Inhibits Hh signaling downstream of Smo and Sufu at the level of Gli (IC₅₀ = 5 µM). GANT61 has also been shown to inhibit the in vitro proliferation of PANC1 and 22Rv1 cells which have elevated GLi11 levels and prevent the development of 22Rv1 tumors in mice.


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