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Product Details
| Cat # +Size | 1892-5 |
|---|---|
| Size | 5 mg |
| Alternate Name | 2,2'-[[dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis(N,N-dimethyl-benzenamine); NSC 136476 |
| Appearance | White to off-white solid |
| CAS # | 500579-04-4 |
| Molecular Formula | C₂₇H₃₅N₅ |
| Molecular Weight | 429.6 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>2 mg/ml) |
| SMILES | CN(C)C1=CC=CC=C1CN2CCCN(C2C3=CC=NC=C3)CC4=CC=CC=C4N(C)C |
| InChi | InChI=1S/C27H35N5/c1-29(2)25-12-7-5-10-23(25)20-31-18-9-19-32(27(31)22-14-16-28-17-15-22)21-24-11-6-8-13-26(24)30(3)4/h5-8,10-17,27H,9,18-21H2,1-4H3 |
| InChi Key | KVQOGDQTWWCZFX-UHFFFAOYSA-N |
| PubChem CID | 421610 |
| MDL Number | MFCD14635408 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A Hedgehog (Hh) signaling pathway antagonist. Inhibits Hh signaling downstream of Smo and Sufu at the level of Gli (IC₅₀ = 5 µM). GANT61 has also been shown to inhibit the in vitro proliferation of PANC1 and 22Rv1 cells which have elevated GLi11 levels and prevent the development of 22Rv1 tumors in mice.
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