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A Hedgehog (Hh) signaling pathway inhibitor
Catalog #: 1812
SKU-Size Size Price Qty
1812-5 5 mg
1812-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name 2,3,4,5-Tetra(4-pyridyl)thiophene; NSC75503
Appearance Yellow solid
CAS # 64048-12-0
Molecular Formula C₂₄H₁₆N₄S
Molecular Weight 392.48
Purity ≥98% by HPLC
Solubility DMSO (25 mM) or Ethanol (25 mM)
InChi InChI=1S/C24H16N4S/c1-9-25-10-2-17(1)21-22(18-3-11-26-12-4-18)24(20-7-15-28-16-8-20)29-23(21)19-5-13-27-14-6-19/h1-16H
PubChem CID 253078
MDL Number MFCD01103196
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC₅₀ ~ 5 µM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.

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