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A STAT3 inhibitor
Catalog #: 2623
SKU-Size Size Price Qty
2623-100 100 µg
2623-500 500 µg
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Product Details

Alternate Name (7bS)-​5,​5aR,​6,​7,​7aR,​7b-​hexahydro-​7b-​hydroxy-​4S-​methyl-​indeno[1,​7-​bc]furan-​2(4H)-​one; NSC645020, NSC-645020
Appearance A white lyophilized solid
CAS # 133613-71-5
Molecular Formula C₁₁H₁₄O₃
Molecular Weight 194.23
Purity >95%
Solubility DMSO
InChi InChI=1S/C11H14O3/c1-6-4-7-2-3-9-11(7,13)8(5-6)10(12)14-9/h5-7,9,13H,2-4H2,1H3/t6-,7+,9+,11-/m1/s1
PubChem CID 6711856
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Galiellalactone is a fungal metabolite that inhibits IL-6-mediated JAK/STAT signal transduction in HepG2 cells (IC₅₀ = 0.25-0.5 μM). The selectivity of this compound is achieved by its ability to block the binding of activated STAT3 dimers to their DNA binding sites without affecting phosphorylation of the STAT3 transcription factor. At 10-50 μM, galiellalactone exhibits dose-dependent growth inhibitory effects on prostate cancer stem cell-like cells expressing active STAT3, suggesting it may be a useful therapeutic approach to control JAK/STAT signaling.

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