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Product Details
| Alternate Name | Galanthamine hydrobromide; Reminyl; (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol;hydrobromide; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol Hydrobromide |
|---|---|
| Appearance | White crystalline solid |
| CAS # | 1953-04-4 |
| Molecular Formula | C₁₇H₂₂BrNO₃ |
| Molecular Weight | 368.27 |
| Purity | ≥ 98% |
| Solubility | ~7 mg/ml in water, ~7 mg/ml in DMSO (may need gentle warming) |
| SMILES | CN1CCC23C=CC(CC2OC4=C(C=CC(=C34)C1)OC)O.Br |
| InChi | InChI=1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1 |
| InChi Key | QORVDGQLPPAFRS-XPSHAMGMSA-N |
| PubChem CID | 121587 |
| MDL Number | MFCD00067672 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20 °C |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Galantamine is an alkaloid originally isolated from the bulbs and flowers of various Galanthus species. It inhibits acetylcholinesterase with an IC₅₀ of 800 nM. It is a potent allosteric potentiating ligand of human α₃β₄, α₄β₂ and α₆β₄ nicotinic receptors (nAChRs). It is used for the treatment of vascular dementia in Alzheimer’s disease.
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