Product Details
| Alternate Name | alpha-Galactosylceramide; αGalCer; KRN7000; (2S,3S,4R)-1-O-(α-D-galactosyl)-N-hexacosanoyl-2-amino- 1,3,4-octadecanetriol |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 158021-47-7 |
| Molecular Formula | C₅₀H₉₉NO₉ |
| Molecular Weight | 858.32 |
| Purity | ≥96% by NMR |
| Solubility | For In vivo assay: Use 5.6% sucrose, 0.75% L-histidine and 0.5% Tween20 with heating at 60-80 ̊C. For In vitro assay: should be dissolved in DMSO at the concentration of 1 mg/ml with heating at 60-80 ̊C . The solution of 1mg/ml in DMSO can be diluted by P |
| SMILES | CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)O)O)O)C(C(CCCCCCCCCCCCCC)O)O |
| InChi | InChI=1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42-,43+,44+,46-,47-,48-,49+,50-/m0/s1 |
| InChi Key | VQFKFAKEUMHBLV-BYSUZVQFSA-N |
| PubChem CID | 2826713 |
| MDL Number | MFCD00939559 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
α-GalCer is a specific ligand for human and mouse natural killer T (NKT) cells; exhibits potent anti-tumor activity with murine in vivo experiments including subcutaneous implanted model and metastatic models in the liver and lung. KRN7000 has been reported to show various immunological effects in infectious diseases, autoimmune disease and graft verse host disease in mice.
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