Product Details
| Alternate Name | apm-1, Adipolean , 30 kDa adipocyte complement-related protein, Adipocyte complement-related 30 kDa protein, Adipocyte, C1q and collagen domain-containing protein, Adipose most abundant gene transcript 1 protein, Gelatin-binding protein, ADIPOQ, ACDC, AC |
|---|---|
| Gene Symbol | ADIPOQ |
| Gene ID | 9370 |
| Accession # | NM_004797 |
| Source | E. coli |
| Appearance | Lyophilized Adiponectin/ gACRP protein |
| Physical Form Description | Sterile filtered and lyophilized Adiponectin/ gACRP30 protein from 10 mM Tris, pH 9.2 + 0.05% Sarcosyl + 0.75 mM DTT |
| Molecular Weight | 16.6 kDa |
| Purity by SDS-PAGE | ≥98% |
| Endotoxin Level | <0.1 ng/μg |
| Biological Activity | Determined by its ability to inhibit the proliferation of murine myeloid cell lines M1. The ED₅₀ for this effect is < 1-3 µg/ml. |
| Reconstitution Instructions | Reconstitute Adiponectin/ gACRP30 protein in water to a concentration of 1 mg/ml. This solution can then be diluted into other aqueous buffers |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Human gAcrp30 (amp-1) also known as Adipolean is a 16.6 kDa protein that corresponds to the C-terminal globular domain of adiponectin (amp-1). gAcrp30/Adipolean is expressed and secreted exclusively by adipose tissue. Adiponectin/ gACRP30 protein possesses unique pharmacological properties for regulation of body weight and lipid metabolism. It is a key component in controlling energy homeostasis. Recently, gAcrp30/Adipolean has been shown to inhibit the proliferation of myelomonocytic progenitors. The Recombinant Human gAcrp30/Adipolean is a 16.6 kDa protein consisting of 145 amino acid residues
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Sánchez-Gurmaches, J. et al. Adiponectin effects and gene expression in rainbow trout: an in vivo and in vitro approach J. Exp. Biol., Apr 2012; 215: 1373 - 1383.
Sevillano J et al. (2007) Endocrinology 10.1210/en. 2007-0352.
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