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Gabexate mesylate

An inhibitor of serine proteases
Catalog #: B3058
SKU-Size Size Price Qty
B3058-50 50 mg
B3058-250 250 mg
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Product Details

Alternate Name FOY; Megacart; ethyl 4-[6-(diaminomethylideneamino)hexanoyloxy]benzoate;methanesulfonic acid; 4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]benzoic acid ethyl ester mesylate; [Ethyl p-(6-guanidinohexanoyloxy) benzoate]methanesulfonate
Appearance White solid
CAS # 56974-61-9
Molecular Formula C₁₇H₂₇N₃O₇S
Molecular Weight 417.48
Purity ≥97%
Solubility ~25 mg/ml in DMSO and DMF
InChi InChI=1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)
PubChem CID 6604561
MDL Number MFCD00210299
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Gabexate is an inhibitor of serine proteases. It inhibits plasma kallikrein, thrombin, plasmin, factor Xa with Ki values of 0.2 μM, 0.97 μM, 1.6 μM and 8.5 μM. It exerts an anticoagulant effect on the clotting activity of thrombin. It inhibits LPS-induced TNF-alpha production in monocytes by inhibiting activation of both NF-kappaB and activator protein-1. It slightly inhibits SARS-CoV-2 S-driven host cell entry in lung cells.

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