Product Details
| Antibody Target | GAAP |
|---|---|
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide at N-terminal |
| Accession # | P55061 |
| Gene ID | 7009 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 100 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2 |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat |
| Application | Western blot |
| Positive Control | Western blot: Jurkat cell lysate, 3T3 cell lysate |
| Application & Usage | Western blot: 1:200 |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The BI-1 (Bax inhibitor 1) family is evolutionarily conserved as integral membrane proteins containing multiple membrane-spanning domains that are predominantly localized to intracellular membranes. BI-1 family members share multiple motifs and transcriptional factors within the promoter and the coding regions. They represent regulators of cell death pathways and are highly conserved in evolution from plants to insects, amphibians, mammals and pox-viruses. GAAP (Golgi anti-apoptotic protein), also known as TMBIM4 (transmembrane Bax inhibitor motif containing 4), S1R, ZPRO or CGI-119, is a 238 amino acid multi-pass membrane protein that belongs to the BI-1 family. Ubiquitously expressed, GAAP inhibits apoptosis induced by intrinsic and extrinsic apoptotic stimuli.
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