G418 Sulfate

An antibiotic and a selection agent

WARNING: This product can expose you to chemicals including G418 sulfate, which is [are] known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

G418 Sulfate is available from Abcam as ab144261.
Catalog #: 1557 | abID:

Product Details

Alternate Name Antibiotic G418, G418
Appearance White to off-white solid
CAS # 108321-42-2
Molecular Formula C₂₀H₄₀N₄O₁₀. 2 H₂SO₄
Molecular Weight 692.71
Purity >720 U/mg (potency)
Solubility H₂O (50 mg/ml)
InChi InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)
PubChem CID 16760463
MDL Number MFCD00058314
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418.

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Tian et al., The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity. J. Biol. Chem., Feb 2014; 289: 3339 - 3351.
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