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G418 Sulfate

based on 2 citations in multiple journalsG418 Sulfate24.1 4
An antibiotic and a selection agent
Catalog #: 1557
SKU-Size Size Price Qty
1557-1G 1 g
$85.00
1557-5G 5 g
$265.00
1557-25G 25 g
$1,070.00
More Sizes Get Quote

Product Details

Alternate Name Antibiotic G418, G418
Appearance White to off-white solid
CAS # 108321-42-2
Molecular Formula C₂₀H₄₀N₄O₁₀. 2 H₂SO₄
Molecular Weight 692.71
Purity >720 U/mg (potency)
Solubility H₂O (50 mg/ml)
SMILES CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O
InChi InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4)
InChi Key UHEPSJJJMTWUCP-UHFFFAOYSA-N
PubChem CID 16760463
MDL Number MFCD00058314
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418.


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Lehman et al., Activation of the Retinoid X Receptor Modulates Angiotensin II-Induced Smooth Muscle Gene Expression and Inflammation in Vascular Smooth Muscle Cells. Mol. Pharmacol., Oct 2014; 86: 570 - 579.
Tian et al., The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity. J. Biol. Chem., Feb 2014; 289: 3339 - 3351.
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