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Product Details
| Alternate Name | Antibiotic G418, G418 |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 108321-42-2 |
| Molecular Formula | C₂₀H₄₀N₄O₁₀. 2 H₂SO₄ |
| Molecular Weight | 692.71 |
| Purity | >720 U/mg (potency) |
| Solubility | H₂O (50 mg/ml) |
| SMILES | CC(C1C(C(C(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)O)O)O.OS(=O)(=O)O.OS(=O)(=O)O |
| InChi | InChI=1S/C20H40N4O10.2H2O4S/c1-6(25)14-11(27)10(26)9(23)18(32-14)33-15-7(21)4-8(22)16(12(15)28)34-19-13(29)17(24-3)20(2,30)5-31-19;2*1-5(2,3)4/h6-19,24-30H,4-5,21-23H2,1-3H3;2*(H2,1,2,3,4) |
| InChi Key | UHEPSJJJMTWUCP-UHFFFAOYSA-N |
| PubChem CID | 16760463 |
| MDL Number | MFCD00058314 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Aminoglycoside antibiotic related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418.
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Lehman et al., Activation of the Retinoid X Receptor Modulates Angiotensin II-Induced Smooth Muscle Gene Expression and Inflammation in Vascular Smooth Muscle Cells. Mol. Pharmacol., Oct 2014; 86: 570 - 579.
Tian et al., The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity. J. Biol. Chem., Feb 2014; 289: 3339 - 3351.
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