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Furin, Human Recombinant

A member of the proprotein convertase family.
Catalog #: P1658
SKU-Size Size Price Qty
P1658-10 10 μg
$145.00
P1658-50 50 μg
$395.00
More Sizes Get Quote

Product Details

Alternate Name Human Recombinant Furin; Recombinant Furin; Furin
Source Insect Cells (sf9)
Physical Form Description Liquid
Molecular Weight 62 kDa (contains His tag at the C-terminus)
Purity by SDS-PAGE ≥ 95%
Endotoxin Level N/A
Biological Activity > 20 mU/mg
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Furin is a member of the proprotein convertase family. As a cellular protease, Furin processes various latent precursor proteins into their biologically active products by cleaving at the RX(K/R)R consensus motif. Some of its substrates are various growth factors, serum proteins, proteases of the blood-clotting and complement systems, matrix metalloproteinases, receptors, viral-envelope glycoproteins, and bacterial exotoxins. Furin play an essential role in embryogenesis and homeostasis and is implicated in various pathologies such as cancer, neurodegenerative diseases and anthrax. A Furin cleavage site (PRRAR) in the SARS-CoV-2 spike protein is considered a key contributor to COVID-19 pathogenesis. The purified human recombinant Furin is a truncated soluble protein (27-574 aa) that lacks the transmembrane domain.


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