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Furamidine dihydrochloride

A selective PRMT1 inhibitor
Catalog #: B2581
SKU-Size Size Price Qty
B2581-5 5 mg
$115.00
B2581-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name 4,4'-(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride
Peptide Sequence N/A
Appearance Yellow solid
CAS # 55368-40-6
Molecular Formula C₁₈H₁₆N₄O.2HCl
Molecular Weight 377.27
Purity ≥98% by HPLC
Solubility >15 mg/ml in Water
>15 mg/ml in DMSO
SMILES C1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N.Cl.Cl
InChi InChI=1S/C18H16N4O.2ClH/c19-17(20)13-5-1-11(2-6-13)15-9-10-16(23-15)12-3-7-14(8-4-12)18(21)22;;/h1-10H,(H3,19,20)(H3,21,22);2*1H
InChi Key VXNYQUQHOUERTR-UHFFFAOYSA-N
PubChem CID 126437
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Furamidine dihydrochloride is a potent, selective and cell-permeable protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 9.4 μM). Displays selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and >400 μM respectively). Inhibits cell proliferation in leukemia cell lines.


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