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Fumagillin

An angiogenesis inhibitor
Catalog #: 2368
$195.00

Product Details

Cat # +Size 2368-1
Size 1 mg
Alternate Name Amebacilin; Fugilin; Fumidil; Fumadil B; NSC9168; U5762
Appearance Off-white solid
CAS # 23110-15-8
Molecular Formula C₂₆H₃₄O₇
Molecular Weight 458.54
Purity ≥98% by NMR
Solubility Ethanol (~ 1 mg/ml)
SMILES CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C
InChi InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1
InChi Key NGGMYCMLYOUNGM-CSDLUJIJSA-N
PubChem CID 6917655
MDL Number MFCD03990453
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Fumagillin is a meroterpenoid antibiotic isolated from Aspergillus fumigatus. An anticancer, antimicrobial, antimalarial and amoebicidal compound. Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP2). Anti-angiogenic by impairing the growth of endothelial cells and altering gene expression. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo.


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