Product Details
| Cat # +Size | 2368-1 |
|---|---|
| Size | 1 mg |
| Alternate Name | Amebacilin; Fugilin; Fumidil; Fumadil B; NSC9168; U5762 |
| Appearance | Off-white solid |
| CAS # | 23110-15-8 |
| Molecular Formula | C₂₆H₃₄O₇ |
| Molecular Weight | 458.54 |
| Purity | ≥98% by NMR |
| Solubility | Ethanol (~ 1 mg/ml) |
| SMILES | CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C |
| InChi | InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1 |
| InChi Key | NGGMYCMLYOUNGM-CSDLUJIJSA-N |
| PubChem CID | 6917655 |
| MDL Number | MFCD03990453 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Fumagillin is a meroterpenoid antibiotic isolated from Aspergillus fumigatus. An anticancer, antimicrobial, antimalarial and amoebicidal compound. Potent, selective and covalent inhibitor of methionine aminopeptidase-2 (MetAP2). Anti-angiogenic by impairing the growth of endothelial cells and altering gene expression. Inhibits endothelial cell proliferation in vitro and tumor-induced angiogenesis in vivo.
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