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A potent VEGFR inhibitor
Catalog #: B1979

In stock

SKU-Size Size Price Qty
B1979-5 5 mg
B1979-25 25 mg
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Product Details

Alternate Name (Z)-6-((6,7-dimethoxyquinazolin-4-yl)oxy)-N,2-dimethylbenzofuran-3-carbimidic acid; HMPL-013
Appearance Crystalline solid
CAS # 1194506-26-7
Molecular Formula C₂₁H₁₉N₃O₅
Molecular Weight 393.39
Purity ≥98% by HPLC
Solubility DMSO (>6 mg/ml)
InChi InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)
PubChem CID 44480399
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Fruquintinib (HMPL-013) is a potent and selective vascular endothelial growth factor receptors1/2/3 (VEGFR 1/2/3) inhibitor with IC₅₀s of 33, 0.35, and 35 nM, respectively. It only weakly inhibits RET, FGFR-1 and c-kit kinases.

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