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FRAX597

A potent group I PAK (p21-activated kinase) inhibitor
Catalog #: B1890

In stock

SKU-Size Size Price Qty
B1890-1 1 mg
$95.00
B1890-5 5 mg
$365.00
More Sizes Get Quote

Product Details

Alternate Name 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
Appearance Yellow solid
CAS # 1286739-19-2
Molecular Formula C₂₉H₂₈ClN₇OS
Molecular Weight 558.1
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=CN=CS4)Cl)NC5=CC=C(C=C5)N6CCN(CC6)C
InChi InChI=1S/C29H28ClN7OS/c1-3-37-27-20(14-24(28(37)38)23-9-4-19(15-25(23)30)26-17-31-18-39-26)16-32-29(34-27)33-21-5-7-22(8-6-21)36-12-10-35(2)11-13-36/h4-9,14-18H,3,10-13H2,1-2H3,(H,32,33,34)
InChi Key DHUJCQOUWQMVCG-UHFFFAOYSA-N
PubChem CID 70934541
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

FRAX597 is a potent group I PAK (p21-activated kinase) inhibitor (IC₅₀ values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively). Displays significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC₅₀ >10 μM for PAK4). FRAX597 inhibits the proliferation of NF2-deficient schwannoma cells in culture and displays potent anti-tumor activity in vivo.


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