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Fotemustine

A chloroethylating agent
Catalog #: B2648
SKU-Size Size Price Qty
B2648-5 5 mg
$95.00
B2648-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name Muphoran; Mustophoran; Diethyl (1-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)phosphonate
Appearance White to off-white solid
CAS # 92118-27-9
Molecular Formula C₉H₁₉ClN₃O₅P
Molecular Weight 315.69
Purity ≥98%
Solubility >1 mg/ml Water
SMILES CCOP(=O)(C(C)NC(=O)N(CCCl)N=O)OCC
InChi InChI=1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14)
InChi Key YAKWPXVTIGTRJH-UHFFFAOYSA-N
PubChem CID 104799
MDL Number MFCD00866278
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Fotemustine is a third generation nitrosourea, chloroethylating agent with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. Fotemustine is lipophilic and crosses the blood-brain barrier.


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