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Fostamatinib Disodium

A potent, ATP-competitive and selective Syk inhibitor
Catalog #: 1936

In stock

SKU-Size Size Price Qty
1936-1 1 mg
$100.00
1936-5 5 mg
$395.00
More Sizes Get Quote

Product Details

Alternate Name (6-((5-Fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl dihydrogen phosphate, disodium
Appearance Off-white solid
CAS # 1025687-58-4
Molecular Formula C₂₃H₂₄FN₆O₉PNa₂
Molecular Weight 624.42
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]
InChi InChI=1S/C23H26FN6O9P.2Na/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29);;/q;2*+1/p-2
InChi Key HSYBQXDGYCYSGA-UHFFFAOYSA-L
PubChem CID 25008120
MDL Number MFCD16628163
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent, ATP-competitive and selective Syk (Spleen tyrosine kinase) inhibitor (IC₅₀ = 41 nM). Inhibits tumor growth in the Eμ- TCL1 transgenic mouse model of CLL by blocking antigen-dependent B-cell receptor signaling.


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