Foretinib

An ATP-competitive multi-kinase inhibitor
Catalog #: 9476 | abID:

Product Details

Alternate Name N-​​[3-​​fluoro-​​4-​​[[6-​​methoxy-​​7-​​[3-​​(4-​​morpholinyl)​propoxy]​-​​4-​​quinolinyl]​oxy]​phenyl]​-​​N'-​​(4-​​fluorophenyl)​-​1,​​1-​​cyclopropanedicarbox​amide; XL-880; GSK1363089G
Appearance White to off-white solid
CAS # 849217-64-7
Molecular Formula C₃₄H₃₄F₂N₄O₆
Molecular Weight 632.65
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
SMILES COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
InChi InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
InChi Key CXQHYVUVSFXTMY-UHFFFAOYSA-N
PubChem CID 42642645
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Foretinib is an ATP-competitive multi-kinase inhibitor that suppresses the activity of hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor-2 (VEGFR-2). In addition, Foretinib suppresses angiogenesis and lymphangiogenesis by blocking VEGFR-2/3 and TIE-2 signaling


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