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FNDC5, human/mouse recombinant

Improves systemic metabolism by increasing energy expenditure.
Catalog #: 7574

Product Details

Cat # +Size 7574-10
Size 10 μg
Alternate Name Fibronectin Type III Domain-containing Protein 5; Fibronectin Type III Repeat-containing Protein 2
Gene Symbol FNDC5
Gene ID 252995
Accession # Q8NAU1
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized in PBS.
Molecular Weight ~16.0 kDa. (extracellular domain, human (aa 32-152) / mouse (aa 29-149)) is untagged. FNDC5 extracellular domain has 100% identity between human, mouse and rat.
Purity by SDS-PAGE ≥95%
Endotoxin Level <0.1 EU/μg by LAL method
Reconstitution Instructions Reconstitute with 100 μl sterile distilled water.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

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