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FNDC4, human/mouse recombinant

An ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin.
Catalog #: 7573
$270.00

Product Details

Cat # +Size 7573-10
Size 10 μg
Alternate Name Fibronectin Type III Domain-containing Protein 4; Fibronectin Type III Repeat-containing Protein 1
Gene Symbol FNDC4
Gene ID 64838
Accession # Q9H6D8
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized in PBS.
Molecular Weight ~16.0 kDa. (Extracellular domain, human (aa 45-167) / mouse (aa 41-163)) is untagged. FNDC4 extracellular domain has 100% identity between human, mouse, rat, dog and monkey.
Purity by SDS-PAGE ≥95%
Endotoxin Level <0.1 EU/μg by LAL method
Reconstitution Instructions Reconstitute with 100 μl sterile distilled water.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure. FNDC4 is an ortholog of FNDC5 with 50% identity and 86% similarity compared to Irisin. FNDC4 as well as FNDC5 are extremely well conserved between species. The function of FNDC4 is unknown. The human FNDC4 gene is highly enriched in liver, brain tissue and adipocytes.


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