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flt3-Ligand, human recombinant

based on 1 citations in multiple journalsflt3-Ligand, human recombinant14.1 4
A member of a small family of growth factors that stimulate the proliferation of hematopoietic cells
Catalog #: 4085

In stock

SKU-Size Size Price Qty
4085-10 10 μg
$190.00
4085-50 50 μg
$495.00
4085-1000 1 mg
$3,600.00
More Sizes Get Quote

Product Details

Alternate Name Fms-related tyrosine kinase 3 ligand, Short name=Flt3 ligand, Short name=Flt3L, SL cytokine
Gene Symbol Flt3-L
Gene ID 2323
Accession # P49771
Source E. coli
Appearance Lyophilized protein
Physical Form Description Sterile filtered and lyophilized with no additives. The protein may appear as a haze of film, which is difficult to see at the bottom of the vial.
Molecular Weight 17.6 kDa
Purity by SDS-PAGE ≥98%
Purity by ≥98%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human AML5 cells is <1.0 ng/ml, corresponding to a specific activity of > 1 x 10⁶ units/mg.
Reconstitution Instructions Reconstitute in H₂O to a concentration of 0.1 – 1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Human flt3-Ligand (flk2-ligand) stimulates the proliferation and colony formation of certain bone marrow precursor cells including CD34+ cells. Recombinant human flt3-ligand is a soluble 17.6 kDa polypeptide containing 155 amino acid residues, which comprises the extraCellular domain of the transmembrane flt3-ligand protein.


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Staron, M. et al. gp96, an Endoplasmic Reticulum Master Chaperone for Integrins and Toll-Like Receptors, Selectively Regulates Early T and B Lymphopoiesis. Blood 2010 115: 2380-2390.
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