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Flavopiridol

A potent CDK inhibitor
Catalog #: 2090
SKU-Size Size Price Qty
2090-1 1 mg
$90.00
2090-5 5 mg
$340.00
More Sizes Get Quote

Product Details

Alternate Name 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4-chromenone; HMR 1275; L86-8275; NSC 649890; Alvocidib
Appearance Yellow solid
CAS # 146426-40-6
Molecular Formula C₂₁H₂₀ClNO₅
Molecular Weight 401.84
Purity ≥98% by HPLC
Solubility DMSO (~15 mg/ml ) or Ethanol (~ 8 mg/ml)
SMILES CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O
InChi InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1
InChi Key BIIVYFLTOXDAOV-YVEFUNNKSA-N
PubChem CID 5287969
MDL Number MFCD00894265
Handling Protect from light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. Flavopiridol is a synthetic flavonoid compound used as an anticancer agent. It is a serine/threonine kinase inhibitor that broadly targets cyclin-dependent kinases (CDKs), including the cyclin 9/cyclin T complex (pTEF-b), preventing activation of RNA polymerase II. Flavopiridol initiates cell cycle arrest and p53-independent apoptosis through down-regulation of Mcl-1 and X-linked inactivator of apoptosis (XIAP).


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