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FK-866

A highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT)
Catalog #: 1914
SKU-Size Size Price Qty
1914-1 1 mg
$70.00
1914-5 5 mg
$195.00
More Sizes Get Quote

Product Details

Alternate Name N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
Appearance White to off-white solid
CAS # 658084-64-1
Molecular Formula C₂₄H₂₉N₃O₂
Molecular Weight 391.51
Purity ≥98% by NMR
Solubility DMSO (>30 mg/ml) and Ethanol
SMILES C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3
InChi InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
InChi Key KPBNHDGDUADAGP-VAWYXSNFSA-N
PubChem CID 6914657
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC₅₀ = ~1 nM).


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