A potent immunosuppresant

FK-506 is available from Abcam as ab120223.
Catalog #: 1563 | abID:

Product Details

Alternate Name Tacrolimus
Appearance White to off-white solid
CAS # 104987-11-3
Molecular Formula C₄₄H₆₉NO₁₂
Molecular Weight 804.02
Purity ≥98%
Solubility DMSO (20 mg/ml)
InChi InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
PubChem CID 445643
MDL Number MFCD11045918
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


A potent immunosuppresant and in vitro T cell proliferation blocker. It disrupts calcineurin-mediated signal transduction in T-lymphocytes. It interacts with its FK506-binding protein-12 (FKBP-12), leading to increase in the release of sarcoplamic reticulum-derived calcium. FK506 and rapamycin, but not cytosporin inhibit aldosterone-stimulated sodium transport in A6 cells. It has been shown to inhibit HCoV-NL63 (coronavirus).

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