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FK-506

A potent immunosuppresant
Catalog #: 1563

In stock

SKU-Size Size Price Qty
1563-1 1 mg
$65.00
1563-10 10 mg
$205.00
More Sizes Get Quote

Product Details

Alternate Name Tacrolimus
Appearance White to off-white solid
CAS # 104987-11-3
Molecular Formula C₄₄H₆₉NO₁₂
Molecular Weight 804.02
Purity ≥98%
Solubility DMSO (20 mg/ml)
SMILES CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC
InChi InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1
InChi Key QJJXYPPXXYFBGM-LFZNUXCKSA-N
PubChem CID 445643
MDL Number MFCD11045918
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent immunosuppresant and in vitro T cell proliferation blocker. It disrupts calcineurin-mediated signal transduction in T-lymphocytes. It interacts with its FK506-binding protein-12 (FKBP-12), leading to increase in the release of sarcoplamic reticulum-derived calcium. FK506 and rapamycin, but not cytosporin inhibit aldosterone-stimulated sodium transport in A6 cells.


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