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Fingolimod (FTY-720A, FTY720)

A novel immune modulator
Catalog #: 1618
SKU-Size Size Price Qty
1618-5 5 mg
$205.00
1618-25 25 mg
$730.00
More Sizes Get Quote

Product Details

Alternate Name FTY-720A, FTY720
Appearance White solid
CAS # 162359-56-0
Molecular Formula C₁₉H₃₃NO₂.HCl
Molecular Weight 343.93
Purity ≥98% by HPLC
Solubility DMSO (100 mg/ml) of EtOH (100 mg/ml)
SMILES CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N.Cl
InChi InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H
InChi Key SWZTYAVBMYWFGS-UHFFFAOYSA-N
PubChem CID 107969
MDL Number MFCD00939512
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

FTY720 can be phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). IC₅₀ of (S)- and (R)- FTY720-phosphate on lymphocyte migration toward 10 nM of S1P are 0.137 nM and 10.98 nM respectively. The IC₅₀ values to cell lines MCF-7 is 6.8±0.6 µM.


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