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FIN56

A ferroptosis inducer
Catalog #: B2308
SKU-Size Size Price Qty
B2308-5 5 mg
$135.00
B2308-25 25 mg
$535.00
More Sizes Get Quote

Product Details

Alternate Name N2,N7-Dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
Appearance White solid
CAS # 1083162-61-1
Molecular Formula C₂₅H₃₁N₃O₅S₂
Molecular Weight 517.66
Purity ≥98%
Solubility DMSO (>40 mg/ml)
SMILES C1CCC(CC1)NS(=O)(=O)C2=CC3=C(C=C2)C4=C(C3=NO)C=C(C=C4)S(=O)(=O)NC5CCCCC5
InChi InChI=1S/C25H31N3O5S2/c29-26-25-23-15-19(34(30,31)27-17-7-3-1-4-8-17)11-13-21(23)22-14-12-20(16-24(22)25)35(32,33)28-18-9-5-2-6-10-18/h11-18,27-29H,1-10H2
InChi Key JLCFMMIWBSZOIS-UHFFFAOYSA-N
PubChem CID 118986699
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

FIN56 is a specific inducer of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). FIN56 activates squalene synthase (SQS) leading to coenzyme Q10 depletion. Also induces degradation of glutathione peroxidase 4 (GPX4), via acetyl-CoA carboxylase (ACC).


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