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Filgotinib

A potent and selective JAK1 inhibitor
Catalog #: 2871
SKU-Size Size Price Qty
2871-10 10 mg
$145.00
2871-50 50 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name N-(5-(4-((1,1-dioxidothiomorpholino)methyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide; GLPG0634
Appearance White to off-white solid
CAS # 1206161-97-8
Molecular Formula C₂₁H₂₃N₅O₃S
Molecular Weight 425.5
Purity ≥98% by HPLC
Solubility DMSO (>25 mg/ml)
SMILES C1CC1C(=O)NC2=NN3C(=N2)C=CC=C3C4=CC=C(C=C4)CN5CCS(=O)(=O)CC5
InChi InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
InChi Key RIJLVEAXPNLDTC-UHFFFAOYSA-N
PubChem CID 49831257
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Filgotinib (GLPG0634) is a potent and selective JAK1 inhibitor; displays >30-fold selectivity for JAk1 over JAK2. GLPG0634 dose-dependently inhibits Th1 and Th2 differentiation and to a lesser extent the differentiation of Th17 cells in vitro.


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