Product Details
| Alternate Name | 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide |
|---|---|
| Appearance | Off-white solid |
| CAS # | 108409-83-2 |
| Molecular Formula | C₁₃H₁₀Cl₂N₂O₄S |
| Molecular Weight | 361.2 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~25 mg/ml) |
| SMILES | CC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl |
| InChi | InChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3 |
| InChi Key | AXNUEXXEQGQWPA-UHFFFAOYSA-N |
| PubChem CID | 3463933 |
| MDL Number | MFCD01212888 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
FH535 is a potent, reversible dual inhibitor of Wnt/β-catenin and a PPARγ and PPARδ signaling. FH535 antagonizes both PPARg and PPARδ ligand-dependent activation and shows structural similarity to GW9662, a known PPARgamma antagonist. The compound is selectively toxic to some carcinomas expressing the Wnt/β-catenin pathway.
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