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FH535

A Wnt pathway antagonist
Catalog #: 2657
SKU-Size Size Price Qty
2657-5 5 mg
$85.00
2657-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Appearance Off-white solid
CAS # 108409-83-2
Molecular Formula C₁₃H₁₀Cl₂N₂O₄S
Molecular Weight 361.2
Purity ≥98% by HPLC
Solubility DMSO (~25 mg/ml)
SMILES CC1=C(C=CC(=C1)[N+](=O)[O-])NS(=O)(=O)C2=C(C=CC(=C2)Cl)Cl
InChi InChI=1S/C13H10Cl2N2O4S/c1-8-6-10(17(18)19)3-5-12(8)16-22(20,21)13-7-9(14)2-4-11(13)15/h2-7,16H,1H3
InChi Key AXNUEXXEQGQWPA-UHFFFAOYSA-N
PubChem CID 3463933
MDL Number MFCD01212888
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

FH535 is a potent, reversible dual inhibitor of Wnt/β-catenin and a PPARγ and PPARδ signaling. FH535 antagonizes both PPARg and PPARδ ligand-dependent activation and shows structural similarity to GW9662, a known PPARgamma antagonist. The compound is selectively toxic to some carcinomas expressing the Wnt/β-catenin pathway.


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