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FGF-basic 147, human recombinant

A growth factor involved in angiogenesis, wound healing and embryonic development
Catalog #: 4036
SKU-Size Size Price Qty
4036-10 10 μg
$115.00
4036-50 50 μg
$260.00
4036-1000 1 mg
$2,045.00
More Sizes Get Quote

Product Details

Alternate Name FGF2, HBGF-2, Prostatropin, Basic fibroblast growth factor, Heparin-binding growth factor 2
Gene Symbol FGF2
Gene ID 2247
Accession # P09038
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from a 10 mM Na2PO4, pH 8.0.
Molecular Weight 16.5 kDa
Purity by SDS-PAGE ≥97%
Endotoxin Level <0.01 ng/μg
Biological Activity EC50 is typically 0.67-1.45 ng/ml. The activity was determined by the dose-dependent stimulation of mouse BALB/c 3T3 cells.
Reconstitution Instructions Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a conce
Amino Acid Sequence MPALPEDGGS GAFPPGHFKD PKRLYCKNGG FFLRIHPDGR VDGVREKSDP HIKLQLQAEE RGVVSIKGVC ANRYLAMKED GRLLASKCVT DECFFFERLE SNNYNTYRSR KYTSWYVALK RTGQYKLGSK TGPGQKAILF LPMSAKS
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Fibroblast Growth Factors, FGFs, are a 22 member family of proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. Although the mechanism remains unclear, FGF-basic 147 (variant of FGF basic 154) is a critical component in keeping embryonic stem cells undifferentiated in cell culture systems. Recombinant human FGF-b 147 (FGF-2) is a non-glycosylated protein, containing 147 amino acids, and having a molecular mass of 16.5 kDa.


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