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FGF-basic 147, Bovine Recombinant

A growth factor involved in angiogenesis, wound healing and embryonic development
Catalog #: P1591
$175.00

Product Details

Cat # +Size P1591-10
Size 10 μg
Alternate Name HBGH-2, HBGF-2, Prostatropin, FGF-2, FGB-b.
Gene Symbol FGF2
Gene ID 281161
Accession # P03969
Source E. coli
Appearance Lyophilized
Physical Form Description Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.
Molecular Weight 16.5 kDa (147 aa)
Purity by SDS-PAGE >97%
Reconstitution Instructions It is recommended to reconstitute the Fibroblast Growth Factor-basic (147 a.a.) in sterile PBS not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Amino Acid Sequence MPALPEDGGS GAFPPGHFKD PKRLYCKNGG FFLRIHPDGR VDGVREKSDP HIKLQLQAEE RGVVSIKGVC ANRYLAMKED GRLLASKCVT DECFFFERLE SNNYNTYRSR KYSSWYVALK RTGQYKLGPK TGPGQKAILF LPMSAKS.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

FGF-basic is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in 5 different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.


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