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FGF-acidic, Bovine Brain

Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration.
Catalog #: P1589
$325.00

Product Details

Cat # +Size P1589-5
Size 5 μg
Alternate Name HBGF-1, ECGF-beta, FIBP, FGFIBP, FIBP-1, ECGF, ECGFA, GLIO703, FGF1, FGF-a, Fibroblast Growth Factor Acidic
Gene Symbol FGF1
Gene ID 281160
Accession # P03968
Source Bovine brain
Appearance Lyophilized
Physical Form Description Lyophilized from 0.5 ml solution containing 1 mM sodium phosphate, pH 7 after filtration over a low binding membrane.
Molecular Weight FGF-1 contains a 17 kDa and a 20 kDa polypeptide chain. The 17 kDa peptide is derived from the 20 K peptide by restricted proteolysis.
Purity by SDS-PAGE >90%
Biological Activity Stimulates growth of bovine capillary endothelial cells by 3-5 fold over 5% calf serum at 10-25ng/ml FGF.
Reconstitution Instructions Reconstitute the lyophilized aFGF in sterile 50 mM Na2HPO4 pH-7, and 0.5% albumin. The Recommended concentration in cell culture: 1-20 ng/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Acidic fibroblast growth factor is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.


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