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FGF-6, human recombinant

Promotes cellular proliferation and differentiation
Catalog #: 7148
SKU-Size Size Price Qty
7148-10 10 μg
$145.00
7148-50 50 μg
$575.00
More Sizes Get Quote

Product Details

Alternate Name Fibroblast Growth Factor-6, HBGF-6, HST-2
Gene Symbol FGF6
Gene ID 2251
Accession # P10767
Source E. coli.
Appearance Lyophilized powder
Physical Form Description Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Tris, pH 7.5, and 50 mM NaCl.
Molecular Weight 18.7 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level < 0.1 ng/μg of protein (<1EU/μg).
Biological Activity Determined by the dose dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors. The expected ED50 is ≤ 0.5 ng/ml corresponding to a specific activity of ≥ 2 x 10^6 units/mg.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in water to a concentration of ≤ 0.5 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier
Amino Acid Sequence MGTRANNTLL DSRGWGTLLS RSRAGLAGEI AGVNWESGYL VGIKRQRRLY CNVGIGFHLQ VLPDGRISGT HEENPYSLLE ISTVERGVVS LFGVRSALFV AMNSKGRLYA TPSFQEECKF RETLLPNNYN AYESDLYQGT YIALSKYGRV KRGSKVSPIM TVTHFLPRI
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

FGF-6 is a secreted heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-6 is expressed in leukemia cell lines with platelet megakaryocytic differentiation potential. It signals through FGFR 1c, 2c, and 4. Recombinant human FGF-6 is an 18.7 kDa protein consisting of 168 amino acid residues.


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