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FGF-21, murine recombinant

based on 1 citations in multiple journalsFGF-21, murine recombinant14.1 4
A heparin binding growth factor, stimulating the proliferation and activation of cells expressing FGFR
Catalog #: 4067
SKU-Size Size Price Qty
4067-10 10 μg
$285.00
4067-50 50 μg
$845.00
4067-1000 1 mg
$5,955.00
More Sizes Get Quote

Product Details

Alternate Name FGF21, Fibroblast growth factor 21, FGFL, UNQ3115/PRO10196
Gene Symbol FGF-21
Gene ID 56636
Accession # Q9JJN1
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from filtered (0.4 mm) solution containing 20 mM Tris, pH 7.4 and 20 mM NaCl
Molecular Weight 20.1 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile H₂O to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Amino Acid Sequence MAYPIPDSSPLLQFGG QVRQRYLYTDDDQDTEAH LEIREDGTVVGAAHRSPE SLLELKALKPGVIQILGV KASRFLCQQPDGALY GSPHFDPEACSFRELL LEDGYNVYQSEAHGL PLRLPQKDSPNQD ATSWGPVRFLPMPGL LHEPQDQAGFLPPE PPDVGSSDPLSMV EPLQGRSPSYAS
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

The FGFs are a family of more than 20 small (~17–26 kDa) secreted peptides. The initial characterization of these proteins focused on their ability to stimulate fibroblast proliferation. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity and, except for FGFR-4, multiple splice isoforms, and FGFR-5, which lacks an intracellular kinase domain. There is growing evidence that FGFRs can be important for regulation of glucose and lipid homeostasis. FGFR-2 appears to be a key molecule during pancreatic development and FGFR-4 has been implicated in cholesterol metabolism and bile acid synthesis. FGF-21 is preferentially expressed in liver, but an exact knowledge of FGF-21 bioactivity and its mode of action have been lacking to date. FGF-21 is a potent activator of glucose uptake on adipocytes, protects animals from diet-induced obesity when overexpressed in transgenic mice, and lowers blood glucose and triglyceride levels when therapeutically administered to diabetic rodents. Fibroblast Growth Factor-21 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 183 amino acids including N-terminal Methionine and having a molecular mass of 20.1 kDa. The amino acid sequence of the recombinant mouse FGF21 is 100% homologous to the amino acid sequence of the mouse FGF21 without signal sequence.The FGF-21 is purified by proprietary chromatographic techniques.


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Stone et al., Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice. Diabetes, Nov 2014; 63: 3721 - 3733.
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