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FGF-2/FGF-basic, human recombinant

Recombinant FGF2 from E.Coli, animal origin free, ≥95% pure, biologically active, cell culture tested. A growth factor involved in angiogenesis, wound healing and embryonic development.
Catalog #: 4037
SKU-Size Size Price Qty
4037-10 10 μg
$80.00
4037-50 50 μg
$205.00
4037-1000 1 mg
$1,250.00
More Sizes Get Quote

Product Details

Alternate Name FGF2, HBGF-2, Prostatropin, Basic fibroblast growth factor, Heparin-binding growth factor 2
Gene Symbol FGF-2
Gene ID 2247
Accession # P09038
Source E. coli
Appearance Recombinant FGF-2 is available as a lyophilized powder
Physical Form Description FGF-2 protein is lyophilized from a 1 mg/ml solution of 5 mM Tris pH 7.6 + 150 mM NaCl
Molecular Weight Human FGF-2 is a 17.2 kDa recombinant protein
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg
Biological Activity The ED₅₀ of human FGF-2 is determined by the dose-dependent proliferation of mouse BALB/c 3T3 cells and is typically less than 3 ng/ml.
Reconstitution Instructions Reconstitute human FGF-2 in 5 mM Tris, pH 7.6 to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

FGF-2 (FGF2, FGF 2, FGF-basic, basic FGF, bFGF) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-2 protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different FGF-2 isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors.


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