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FGF-2/FGF-basic, Bovine Pituitary

A growth factor involved in angiogenesis, wound healing and embryonic development
Catalog #: P1590
$455.00

Product Details

Cat # +Size P1590-5
Size 5 μg
Alternate Name FGF2, HBGF-2, Prostatropin, Basic fibroblast growth factor, Heparin-binding growth factor 2
Gene Symbol FGF-2
Gene ID 281161
Accession # P03969
Source Bovine Pituitary.
Appearance Lyophilized
Physical Form Description Lyophilized from a concentrated sterile solution containing 50mM Na2HPO4, pH-7.5 & 0.5% HSA.
Molecular Weight 16 kDa
Purity by SDS-PAGE 95%
Biological Activity The recommended concentration in responsive cells is 0.1 to 2 ng/ml.
Reconstitution Instructions It is recommended to reconstitute the lyophilized FGF-2 Bovine in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

FGF-basic is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from AUG and non-AUG (CUG) initiation codons resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. there are differences in the tissue distribution and concentration of these 2 growth factors.


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