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Product Details
| Alternate Name | Fibroblast Growth Factor-18, zFGF5, FGFI, UNQ420/PRO856 |
|---|---|
| Gene Symbol | FGF-18 |
| Gene ID | 8817 |
| Accession # | O76093 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized from 10 mM Tris pH 8.0. The protein may appear as a haze or film, which you may not see at the bottom of the vial. |
| Molecular Weight | 21.2 kDa |
| Purity by SDS-PAGE | ≥95% |
| Purity by | ≥95% |
| Endotoxin Level | <0.1 ng/μg |
| Biological Activity | The ED₅₀ as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is <0.5 ng/ml, corresponding to a specific activity of >2 x 10⁶ units/mg. |
| Reconstitution Instructions | Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
The FGFs plays an important role in regulating tissue growth, morphogenesis and tissue repair. FGF-18 is a newly discovered heparin binding growth factor that stimulates the proliferation and activation of cells that express FGF receptors. The human FGF-18 is a 21.2 kDa protein containing 182 amino acid residues.
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Kaixuan Shi. PAX8 regulon in human ovarian cancer links lineage dependency with epigenetic vulnerability to HDAC inhibitors. eLife May-19. 31050342.
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