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A prostaglandin D2 (PGD2) receptor antagonist
Catalog #: B1588

In stock

SKU-Size Size Price Qty
B1588-5 5 mg
B1588-25 25 mg

Product Details

Alternate Name 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid; NVP-QAW039; QAW039
Appearance White to of-white solid
CAS # 872365-14-5 
Molecular Formula C₁₉H₁₇F₃N₂O₄S 
Molecular Weight 426.41
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1=C(C2=C(N1CC3=C(C=C(C=C3)S(=O)(=O)C)C(F)(F)F)N=CC=C2)CC(=O)O
InChi InChI=1S/C19H17F3N2O4S/c1-11-15(9-17(25)26)14-4-3-7-23-18(14)24(11)10-12-5-6-13(29(2,27)28)8-16(12)19(20,21)22/h3-8H,9-10H2,1-2H3,(H,25,26)
PubChem CID 23582412
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Fevipiprant is a prostaglandin D2 (PGD2) receptor antagonist with a Kd value of 1.14 nM for CRTH2/DP2. It has been shown to inhibit PGD2-stimulated human eosinophil shape change in whole blood assays (IC₅₀ = 0.44 nM) and to inhibit PGD2-induced cytokine release in human Th2 cells (IC₅₀s = 2.56 and 1.4 nM for IL-5 and IL-13, respectively). This compound has undergone testing in a phase II clinical study in uncontrolled allergic asthma.

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