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FB23-2

A FTO inhibitor
Catalog #: B2740
SKU-Size Size Price Qty
B2740-1 1 mg
$75.00
B2740-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name FB-232; 2-((2,6-dichloro-4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-N-hydroxybenzamide; FTO inhibitor
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 2243736-45-8
Molecular Formula C₁₈H₁₅Cl₂N₃O₃
Molecular Weight 392.24
Purity ≥98%
Solubility >50 mg/ml DMSO
SMILES O=C(NO)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)ON=C3C)C=C2Cl
InChi InChI=1S/C18H15Cl2N3O3/c1-9-16(10(2)26-23-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(24)22-25/h3-8,21,25H,1-2H3,(H,22,24)
InChi Key ILHNIWOZZKIBNW-UHFFFAOYSA-N
PubChem CID 138454779
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

FB23-2 is a potent FTO (fat mass and obesity-associated) inhibitor. FB23-2 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity (IC50 = 2.6 µM). Mimicking FTO depletion, FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells in vitro.


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