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Fasudil, Monohydrochloride

A Rho kinase (ROCK) inhibitor
Catalog #: 1787
SKU-Size Size Price Qty
1787-10 10 mg
$95.00
1787-50 50 mg
$345.00
More Sizes Get Quote

Product Details

Alternate Name 1-(5-Isoquinolinesulfonyl)homopiperazine, Monohydrochloride Salt; HA-1077, Monohydrochloride; AT-877
Appearance White to off-white solid
Formulation Water (175 mg/ml) or DMSO (10 mg/ml)
CAS # 105628-07-7
Molecular Formula C₁₄H₁₇N₃O₂S•HCl
Molecular Weight 327.83
Purity ≥99% by HPLC
Solubility Water (175 mg/ml) or DMSO (10 mg/ml)
SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
InChi InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
InChi Key LFVPBERIVUNMGV-UHFFFAOYSA-N
PubChem CID 163751
MDL Number MFCD00943198
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A cell-permeable Ca²⁺ antagonist and vasodilator. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), myosin light chain kinase (Ki = 36 µM) and Rho kinase (ROCK; IC₅₀ = 10.7 µM. Fasudil also mobilizes adult neural stem cells in vivo.


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