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Product Details
| Alternate Name | 1-(5-Isoquinolinesulfonyl)homopiperazine, Monohydrochloride Salt; HA-1077, Monohydrochloride; AT-877 |
|---|---|
| Appearance | White to off-white solid |
| Formulation | Water (175 mg/ml) or DMSO (10 mg/ml) |
| CAS # | 105628-07-7 |
| Molecular Formula | C₁₄H₁₇N₃O₂S•HCl |
| Molecular Weight | 327.83 |
| Purity | ≥99% by HPLC |
| Solubility | Water (175 mg/ml) or DMSO (10 mg/ml) |
| SMILES | C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl |
| InChi | InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H |
| InChi Key | LFVPBERIVUNMGV-UHFFFAOYSA-N |
| PubChem CID | 163751 |
| MDL Number | MFCD00943198 |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A cell-permeable Ca²⁺ antagonist and vasodilator. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), myosin light chain kinase (Ki = 36 µM) and Rho kinase (ROCK; IC₅₀ = 10.7 µM. Fasudil also mobilizes adult neural stem cells in vivo.
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