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FasL Antibody

Catalog #: 3345R
SKU-Size Size Price Qty
3345R-30T 30 µg
$89.00
3345R-100 100 µg
$245.00
More Sizes Get Quote

Product Details

Antibody Target FasL
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide mapping to the C-terminus of rat FasL
Accession # P41047
Gene ID 14103
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin
Purification Affinity purified
Species Reactivity Mouse, rat
Application Western blot
Application & Usage Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Detects ~31 kDa FasL in samples of mouse and rat origins. A ~70 kDa band, possible represents the FasL and Fas complex can also be detected
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Fas/Apo-1/CD95 is a cell surface type-I membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS-PAGE. Fas is a member of the TNFR family that includes TNFR1, TNFR2, CD27, CD30, and CD40. Binding of Fas-ligand (FasL) to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies leads to apoptosis in Fas expressing cells. Both Fas and TNF-R contain the 70 amino acids cytoplasmic “death domain” that is responsible for transmitting signal for apoptosis.


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Diwaker et al., Effect of modulation of unfolded protein response pathway on dengue virus infection.  Acta Biochim Biophys Sin, Oct 2015; 10.1093/abbs/gmv108.
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