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Fasiglifam (TAK-875)

A potent and selective GPR40 agonist
Catalog #: B1280
SKU-Size Size Price Qty
B1280-5 5 mg
$125.00
B1280-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name  (S)-2-(6-((2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid
Appearance Crystalline solid
CAS # 1000413-72-8
Molecular Formula C₂₉H₃₂O₇S
Molecular Weight 524.63
Purity ≥97% by HPLC
Solubility DMSO
SMILES CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCCCS(=O)(=O)C
InChi InChI=1S/C29H32O7S/c1-19-12-25(34-10-5-11-37(3,32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24/h4,6-9,12-14,16,23H,5,10-11,15,17-18H2,1-3H3,(H,30,31)/t23-/m1/s1
InChi Key BZCALJIHZVNMGJ-HSZRJFAPSA-N
PubChem CID 24857286
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Fasiglifam (TAK-875) is a potent and selective agonist of GPR40 with EC₅₀ of 14 nM, 400-fold more potent than oleic acid. TAK-875 displays potent plasma glucose-lowering action and insulinotropic action during an oral glucose tolerance test in female Wistar fatty rats with impaired glucose tolerance.


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