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A competitive inhibitor of histamine H2-receptor
Catalog #: B3021
SKU-Size Size Price Qty
B3021-1G 1 g
B3021-5G 5 g
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Product Details

Alternate Name 3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N'-sulfamoylpropanimidamide; pepcid; N'-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine; 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide; (1Z)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropanimidamide; MK-208; YM-11170
Appearance White to Off-White Powder
CAS # 76824-35-6
Molecular Formula C₈H₁₅N₇O₂S₃
Molecular Weight 337.45
Purity ≥98%
Solubility ~30 mg/ml in DMSO
InChi InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)
PubChem CID 5702160
MDL Number MFCD00075320
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Famotidine is a competitive inhibitor of histamine H2-receptor located on the basolateral membrane of the parietal cells. Famotidine inhibits histamine-induced acid secretion in isolated canine parietal cells with an IC₅₀ of 0.6 µM. It suppresses histamine-induced gastric acid secretion in dogs and anesthetized rats with ID₅₀ values of 10 and 400 µg/kg, respectively. It is used to treat ulcers, gastroesophageal reflux disease and heartburn. Famotidine is also being investigated in clinical trials for treatment against COVID-19.

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