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Factor XIIa, Human Plasma

Activates prekallikrein to kallikrein
Catalog #: 7691

Product Details

Cat # +Size 7691-250
Size 250 μg
Alternate Name Hageman factor
Gene Symbol F12
Gene ID 2161
Accession # P00748
Source Human Plasma
Appearance Liquid
Physical Form Description In 4 mM Sodium Acetate-HCl, 0.15 M NaCl, pH 5.3.
Molecular Weight 80.00 kDa
Purity by SDS-PAGE ≥95%
Biological Activity Lot dependent
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans


Human Factor α-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system. Human Factor XII and prekallikrein are thought to be involved in a reciprocal activation mechanism in which Factor XIIa activates prekallikrein to kallikrein, which in turn converts Factor XII to XIIa. Factor XIIa activates Factor XI to XIa thereby triggering the Contact Factor cascade.

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