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Factor Va, Human Plasma

A serine protease co-ordinating multiple physiological functions
Catalog #: 4098
SKU-Size Size Price Qty
4098-10 10 μg
$215.00
4098-50 50 μg
$660.00
More Sizes Get Quote

Product Details

Alternate Name Activated protein C cofactor, Proaccelerin (labile factor)
Gene Symbol F5
Gene ID 2153
Accession # P12259
Source Human plasma
Appearance Liquid
Physical Form Description In 5 mM CaCl2 +50% glycerol
Molecular Weight 94.0 kDa (heavy chain), 74.0 kDa (light chain)
Purity by SDS-PAGE ≥95%
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Factor Va is a cofactor for the serine protease factor Xa, and in the presence of calcium ions they collectively assemble on a phospholipid surface to form the prothrombinase complex. The prothrombinase complex is responsible for the rapid conversion of prothrombin to thrombin. Factor Va is derived from the pro-cofactor, factor V, upon limited proteolysis by alpha-thrombin. The thrombin cleavage of factor V liberates two heavily glycosylated activation peptides from the central portion of the molecule which have no cofactor function. Factor Va is comprised of an NH2-terminal derived heavy chain (Mr=94,000) and a COOH-terminal derived light chain (Mr=74,000) which remain associated in the presence of calcium ions. The cofactor binds to phospholipid (cell membrane) surfaces and effectively serves as a receptor for membrane bound factor Xa. Complete assembly of the prothrombinase complex (factor Xa, factor Va, phospholipid, and calcium) results in a 300,000-fold increase in the rate of prothrombin conversion relative to the rate observed with factor Xa alone. The interaction between factor Va and factor Xa is mediated by both the heavy and light chain of factor Va, while the binding of prothrombin to factor Va is mediated solely by the heavy chain.


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