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FAAH1 Inhibitor Screening Kit (Fluorometric)

for high-throughput screening of Fatty Acid Amide Hydrolase inhibitors
Catalog #: K379
$495.00

Product Details

Cat # +Size K379-100
Size 100 assays
Kit Summary Fatty Acid Amide Hydrolase (FAAH; EC: 3.5.1.99), also known as Oleamide Hydrolase or Anandamide Amidohydrolase is a member of the serine hydrolase family of enzymes. It is an integral membrane enzyme that hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. Endocannabinoids are endogenous lipid ligands that activate the Cannabinoid G-protein coupled Receptors (CB). CB1 and CB2 modulate physiological and behavioral processes such as pain, anti-inflammation etc. In addition to hydrolyzing Endocannabinoids, FAAH regulates other lipid signaling molecules with anti-inflammatory and analgesic properties. Recent study suggests that FAAH may represent an attractive therapeutic target for treatment of pain, inflammation etc. In BioVision’s Human FAAH1 Inhibitor Screening Kit, FAAH1 hydrolyzes a non-fluorescent substrate to generate a fluorescent product, 7-amino-4-methylcoumarin, which can be measured at Ex/Em = 360/465 nm. In the presence of FAAH1 Inhibitor, the reaction is impeded. The assay is high-throughput adaptable and can be completed in less than 1 hr.
Detection Method Fluorescence (Ex/Em = 360/465 nm)
Species Reactivity Mammalian
Applications Screening/characterizing/studying potential inhibitors of Human FAAH1
Features & Benefits • Simple
• Reliable test suitable for high-throughput screening of FAAH1 inhibitors
• Sensitive
• Rapid
Kit Components FAAH1 Inhibitor Control
Human FAAH1
FAAH1 Assay Buffer
FAAH1 Substrate
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Fatty Acid Amide Hydrolase (FAAH; EC: 3.5.1.99), also known as Oleamide Hydrolase or Anandamide Amidohydrolase is a member of the serine hydrolase family of enzymes. It is an integral membrane enzyme that hydrolyzes the endocannabinoid anandamide and related amidated signaling lipids. Endocannabinoids are endogenous lipid ligands that activate the Cannabinoid G-protein coupled Receptors (CB). CB1 and CB2 modulate physiological and behavioral processes such as pain, anti-inflammation etc. In addition to hydrolyzing Endocannabinoids, FAAH regulates other lipid signaling molecules with anti-inflammatory and analgesic properties. Recent study suggests that FAAH may represent an attractive therapeutic target for treatment of pain, inflammation etc. In BioVision’s Human FAAH1 Inhibitor Screening Kit, FAAH1 hydrolyzes a non-fluorescent substrate to generate a fluorescent product, 7-amino-4-methylcoumarin, which can be measured at Ex/Em = 360/465 nm. In the presence of FAAH1 Inhibitor, the reaction is impeded. The assay is high-throughput adaptable and can be completed in less than 1 hr.


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